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Semaglutide, liraglutide, and dulaglutide have demonstrated cardiovascular benefits in clinical trials, with Wegovy (semaglutide 2.4 mg) recently receiving FDA approval for cardiovascular risk reduction in adults with established cardiovascular disease and obesity

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And a multi-year study found that one type of GLP-1 agonist (semaglutide) reduced the risk of heart attack and stroke by 20 percent

Future research directions include direct comparative trials between various GLP-1 RAs and multi-agonists in MASLD populations to identify optimal therapeutic choices for specific patient subgroups

How Semaglutide GLP-1 Works: Appetite Suppression: By activating GLP-1 receptors in the brain, semaglutide increases the feeling of fullness and reduces hunger, significantly decreasing food intake