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Adult mice (810 weeks old) were given drinking water for 3 weeks with the cocktail of broad-spectrum antibiotics, including ampicillin (1 g/L, Sigma-Aldrich), vancomycin (0.5 g/L, China Chemical & Pharmaceutical Co., Ltd), neomycin (1 g/L, Fisher Scientific), and metronidazole (0.5 g/L, Acros Organics)

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