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Clinical trials show average weight loss of 15% body weight for Semaglutide and up to 22% for Tirzepatide over 68 to 72 weeks

Healthcare providers can prescribe both medications together when clinically indicated, but this combination necessitates enhanced glucose monitoring, particularly during niacin initiation or dose escalation

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The trial tracked 17,604 adults ages 45 and older who had overweight or obesity and a cardiovascular condition, but no history of diabetes