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Notably, proglucagon is cleaved in an alternative fashion by PC2 in pancreatic cells to yield glucagon, but not GLP-1/2

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Abstract Purpose of Review The pharmacologic management of type 2 diabetes prioritises sodium-glucose cotransporter 2 (SGLT-2) inhibitors or glucagon-like peptide 1 (GLP-1) receptor agonists for their demonstrated cardiovascular benefits in individuals with atherosclerotic cardiovascular disease or multiple cardiovascular risk factors, chronic kidney disease, and heart failure

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