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Bell et al., 1983b)

Consultations are more thorough, and the prescribing physicians actively adjust protocols based on patient response

All existing research has been conducted in mice, with no long-term human safety trials and no established safe doses for humans

Abbreviations DPP-4: Dipeptidyl peptidase 4 CGM: Continuous glucose monitoring T2DM: Type 2 diabetes mellitus d-ROMs: Diacron-reactive oxygen metabolites DTSQ: Diabetes Treatment Satisfaction Questionnaire CVD: Cardiovascular disease GLP-1RA: Glucagon-like peptide-1 receptor agonist HbA1c: Glycated hemoglobin BW: Body weight FPG: Fasting plasma glucose SD: Standard deviation MGL: Mean glucose level MAGE: Mean amplitude of glycemic excursions MODD: Mean of daily difference of blood glucose TAR: Time above range TIR: Time in range BMI: Body mass index HDL-C: High-density lipoprotein cholesterol LDL-C: Low-density lipoprotein cholesterol eGFR: Estimated glomerular filtration rate %CV: Percentage coefficient of variation for glucose References Rawshani A, Rawshani A, Franzn S, Eliasson B, Svensson AM, Miftaraj M, et al

GLP-1 secretion is stimulated by nutrient intake and exerts its effects on glucose homeostasis by stimulating insulin secretion, gastric emptying confiding the food intake, and -cell proliferation