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Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP) Obesity (Silver Spring) 2012;20(2):330342

20 In agreement with the ADA, the American Association of Clinical Endocrinologists (AACE) lists DPP-4 inhibitors as an alternative in patients with an A1C under 7.5% in whom the use of metformin is contraindicated

Pharmacological alternatives include: Orlistat : A lipase inhibitor that reduces dietary fat absorption by approximately 30%

This challenges the conventional view that obesity alone drives metabolic complications in HS, underscoring the metabolic burden HS imposes independently of body weight [6]

This article explores the current availability of GLP-1 medications in Canada, the legal and regulatory hurdles for U.S