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Mechanistic studies suggest that the potential direct cardiovascular benefits of SGLT2i include augmentation of signal transducer and activator of transcription 3 (STAT3), inhibition of sodium hydrogen exchange (sodium-hydrogen antiporter 1 [NHE-1]), improved mitochondrial metabolism, modulation of natriuretic peptides, improved vascular stiffness and autonomic tone, reduction of inflammation, and improved cardiac energetics

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When tapering off this weight loss drug, the following steps are vital: Consult your healthcare provider : Before making any changes to your GLP-1 medication dosage, always seek guidance from your healthcare provider to make sure a safe and effective shift

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