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Description
Onoviran OF et al
Personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or severe gastrointestinal conditions like gastroparesis may rule out tirzepatide and similar GLP-1 based therapies
In a phase 2 trial, Rosenstock et al
In the SURPASS clinical trials for type 2 diabetes, nausea occurred in 1222% of patients, diarrhea in 1216%, and vomiting in 59%, with incidence varying by dose
standard deviation [SD], 3.5 years
