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[11] performed studies in humans and confirmed GLP-1 (7-36) to be insulinotropic, suggesting its incretin nature

Combination with insulin may be necessary in patients with advanced beta cell dysfunction, though the dual agonism effects may reduce insulin requirements compared to traditional approaches

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Compounded semaglutide or tirzepatide from 503A pharmacies may be options for eligible patients under clinical supervision and with appropriate monitoring

GLP-1 effects on the brain The GLP-1 receptor is expressed in the hypothalamus, brainstem, and other parts of the central nervous system, helping GLP-1 drugs to reduce body weight by decreasing hunger and increasing feelings of satiety