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This isn't a willpower issue
Athauda and colleagues 26 reported that exenatide 2 mg once weekly had numerically greater improvements in individual domains assessing mood/depression across all observer rated outcome measures including the mood/apathy domain of the Non-Motor Symptoms Scale in Parkinson Disease

Persistence and Discontinuation: Two Sides of the GLP-1 Cost Equation A: It depends

But Trapps lab discovered a critical flaw: preproglucagon (PPG) neurons, which produce GLP-1 in the brainstem, lack receptors for circulating GLP-1

Although an increase in heart-rate per se is not a major problem for most people, it is salient in the case of GLP1R, GIPR or GR agonists since the target patient population of these agonist are obese patients, who likely already suffer from cardiovascular complications
