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In PIONEER 4, 14 mg oral semaglutide was compared with 1.8 mg liraglutide (1.2% vs 0.9% HbA1c reduction, 5 kg vs 3.1 kg weight loss) and was found to provide comparable glycemic control and significant weight loss
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A.EvansA.EidN.Sadeghi-NejadH.et al (2023)
4.4.2 Mechanistic hypotheses and clinical positioning Animal studies suggest that GLP-1RAs may restore ovulation by reducing local ovarian lipotoxicity and inflammatory/oxidative stress loads, thereby improving autophagy and PI3K/AKT/mTOR-related imbalances (131)
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