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Effects of acarbose on the gut microbiota of prediabetic patients: a randomized, double-blind, controlled crossover trial

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16 On the other hand, the investigational use of GIPR agonists (GIPRAs) has not yielded similar advantages, partly because of a lack of understanding of GIP dose-response actions

Strategies on how to manage these and other side effects are described in more detail here: Figure 3 of this article and Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with Glp-1 Receptor Agonists

The development of multiagonists, including GLP-1glucagon and GIPGLP-1glucagon receptor agonists, especially with the potential for glucagon receptor activation, marks a significant advancement in the field