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TOPIRAMATE may decrease the density of bones when used over a long period

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Adverse effects may occur, such as an increased risk of non-sexually transmitted genital infections and/or urinary infections, an increased risk of hypotension, and in rare cases, diabetic ketoacidosis [101]

Stock solutions of Fmoc-protected amino acids and coupling reagents were freshly prepared before each synthesis using ultrapure peptide grade DMF (0.5 M and 0.45 M, respectively)
