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237 Another target of SIRT2 is HIF1 in the cytosol, promoting the hydroxylation and degradation of HIF1 and suppressing the tumor growth dependent on hypoxia
Seek urgent medical advice (contact your GP or NHS 111) if you experience: Severe or persistent abdominal pain, especially if accompanied by vomiting Persistent vomiting or inability to keep fluids down Signs of dehydration (extreme thirst, dark urine, dizziness) Sudden severe upper abdominal pain radiating to the back (possible pancreatitis) Severe right upper abdominal pain (possible gallstones) Severe bloating with vomiting and no passage of stool or gas (possible obstruction) Persistent or severe gastrointestinal symptoms may indicate the need for dose adjustment or, rarely, discontinuation of therapy
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Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review
doi: 10.1016/j.phrs.2022.106320 [DOI] [PubMed] [Google Scholar] 74
