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Skyes CB1 Inhibitor, Nimacimab, Demonstrates Superior Weight Loss and Differentiated Mechanisms from Monlunabant, and Continues to Show Enhanced Combination with Tirzepatide with Durable Post-Treatment Weight Maintenance in DIO Model Skye shares new preclinical DIO data at virtual KOL event Nimacimab + tirzepatide demonstrates over 40% weight loss in multiple preclinical DIO studies Nimacimab demonstrates durable post-treatment weight loss compared to tirzepatide Nimacimab reduced rebound weight gain following treatment with tirzepatide or nimacimab + tirzepatide Nimacimab outperformed monlunabant head-to-head, and is uniquely positioned as a well-tolerated therapeutic to potentially induce healthier and sustained weight loss, both as a monotherapy, combination and maintenance therapy Top-line data from Phase 2 CBeyond TM study expected to be reported in late Q3/early Q4 2025 SAN DIEGO, Sept

Someone who loses 50 pounds in five months may experience more pronounced adaptation than someone who loses the same amount over twelve months

In women, the fibrous cords that connect skin to muscle are arranged in a vertical pattern, making it easier for fat cells to bulge through and create dimples

GLP-1 agonists can contribute to lean mass loss alongside fat loss if resistance training and adequate protein intake are not maintained

and the potential to exacerbate social isolation