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Isaacs says that while most people can safely take a GLP-1, you should avoid it if you have severe gastroparesis (stomach paralysis)

Others feel terrible for the first few days after every increase

For deficiency without neurological involvement or for borderline levels, oral supplementation with high-dose cyanocobalamin (1000-2000 mcg daily) is often effective, as approximately 1% of an oral dose is absorbed through passive diffusion even in the absence of intrinsic factor

If additional glycemic control is needed: Increase from 5 mg to 7.5 mg subcutaneously for 4 weeks and thereafter in 2.5 mg increments after at least 4 weeks on the current dose
