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While the consistency of the association across comparator therapies and the scale of the dataset support the signals clinical relevance, biological plausibility remains hypothesis-generating and is based on investigator interpretation rather than validated mechanistic evidence

Exenatide immediate-release (Byetta): Initiation involves a 5 mcg dose administered subcutaneously twice daily, which can be increased to 10 mcg twice daily after a month if required

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The Harmony Outcomes Trial, conducted in 2018, investigated the use of 3050 mg albiglutide once-weekly subcutaneous injection in 9463 patients with T2DM for a median of 1.5 years