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While these questions remain unanswered, one thing is clear: GLP-1RAs challenge the conventional approach to AUD treatment, offering an avenue that aligns more closely with real-world drinking behaviors and patient needs

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4 MERCS as a structural signaling platform to GLP-1 receptor Contemporary understanding of the GLP-1R has transitioned from a model of linear, diffuse signaling at the plasma membrane to a sophisticated architecture of spatiotemporally organized nanodomains known as signalosomes ( 2+ flux, lipid transport, and bioenergetic restoration