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Future directions Future research directions for the use of GLP-1R agonists in the treatment of pain and headache disorders should focus on conducting human trials to evaluate their efficacy and safety, particularly in individuals with comorbid obesity [60]

The Novo Nordisk Foundation Center for Protein Research is supported financially by the Novo Nordisk Foundation (grant number NNF14CC0001)

doi:10.1001/jama.2023.24945 Busetto L, Bettini S, Makaronidis J, Roberts CA, Halford JCG, Batterham RL

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