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This is particularly surprising given that i.c.v administration is a standard route to test central effects of drugs in animal studies, and a large number of studies have injected GLP1 or GLP1 receptor agonists and antagonists into the ventricular system in order to explore direct effects of GLP1 receptor activation within the CNS (Meeran et al., 1999

Many of these incidents involved dosing errors, especially when vials and syringes were used instead of pre-filled pens

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Notably, administering sucrose in the drinking water to SPF mice did not yield any significant alterations in their locomotor behavior (Supplementary Fig
Int J Obes (2012) 36:84354
