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In the direct comparison of tirzepatide versus semaglutide, we observed CIs compatible with no difference and point estimates indicating a modest numeric advantage of semaglutide, if any, for reducing MACE, particularly among patients at high cardiovascular risk
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Review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists

Appetite control improves further, cravings reduce, and eating patterns become more structured
