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pharmacovigilance study analyzing 15,597 tirzepatide reports found no significant signals for depression or suicidality and a mortality rate of just 0.26% , lower than other anti-obesity medications

For lipid outcomes, tirzepatide 15 mg was associated with statistically or numerically improved efficacy versus semaglutide whereas there was no clear trend for tirzepatide 5 and 10 mg

However, some patients experience diminishing returns or gastrointestinal side effects that prevent comfortable dose escalation

The most effective approach is consistency, not speed

As a relatively new medication approved by the FDA in 2022, limited data exist regarding its safety during breastfeeding