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Drugs and Lactation Database (LactMed) [Internet]

Choose Semaglutide If: You want the medication with the longer real-world safety record and more accumulated clinical data You've had previous GI sensitivity to medications and want to start with the option that may be slightly better tolerated You have a strong cardiovascular history and your provider wants the extensive SUSTAIN cardiovascular outcomes data behind your treatment You've already tried semaglutide and responded well there's no reason to switch what's working Choose Tirzepatide If: You want the medication with the strongest average weight loss outcomes in clinical trials You have significant insulin resistance or type 2 diabetes where the dual GIP/GLP-1 mechanism provides added metabolic benefit You've plateaued on semaglutide and want to try the additional GIP pathway You're comfortable with a newer medication that has a rapidly growing and compelling safety and efficacy record Not Sure Which Is Right for You