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Patient counseling should include: Realistic expectations about generalized rather than targeted fat loss The importance of combining medication with lifestyle modifications Recognition that individual response varies based on genetics, baseline body composition, and adherence Understanding that sustainable results require long-term commitment For optimal outcomes, GLP-1 therapy should be integrated into a comprehensive weight management program that includes nutritional counseling, regular physical activity (particularly resistance training to preserve lean muscle mass), behavioral therapy, and ongoing medical supervision

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This leads to loss of water balance