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[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Tonneijck L., Muskiet M.H.A., Twisk J.W., et al

This dual action slows gastric emptying, meaning food stays in your stomach longer and sends prolonged fullness signals to your hypothalamus

Some research shows that tirzepatide may help people lose more of their body weight (15% or more of their starting weight) compared with semaglutide

You can stay at the lower dose longer if you need time to adjust

But if you already supplement B12 orally or your blood work shows adequate B12 levels, niacinamide offers benefits that B12 does not, particularly around cellular energy and NAD+ support