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If the patient is a nonresponder to an adequate trial of the additional agent (no clinically meaningful reduction in A1C), that agent should be discontinued and an alternative agent added to metformin
The American Academy of Pediatrics does not list semaglutide or tirzepatide on its contraindicated-medication database
doi: 10.1038/ijo.2012.205 102 VasuSMoffettRCThorensBFlattPR
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Studies show that between 40 to 70% of people experience gastrointestinal issues such as nausea, vomiting, diarrhea, constipation, and bloating
