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doi: 10.1136/tsaco-2018-000219

Both receptors exist in brain regions that regulate appetite, and their combined activation produces stronger appetite suppression than targeting either receptor alone
Lingvay, J

However, standard fasting guidelines alone are often inadequate to prevent delayed gastric emptying and aspiration risk in all patients, thereby necessitating objective evaluations such as preoperative gastric ultrasonography

The combination of GIP and glucagon receptor activation appears to produce additive benefits for liver fat reduction and metabolic health that neither receptor achieves alone