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Glucagon-like peptide-1 (GLP-1) production, which determines postprandial glucose levels, is regulated by intestinal homeostasis

Exclusion criteria included type 1 or other types of diabetes mellitus, history of pancreatitis, and family or personal history of type 2 multiple endocrine neoplasia syndrome or medullary thyroid cancer

There is solid support for gastroparesis, stomach paralysis, gastrointestinal obstruction, and ileus (bowel obstruction)

Brand-name medications referenced throughout this guide (Wegovy, Ozempic, Mounjaro, Zepbound) are trademarks of their respective owners

Biased Agonism at the GLP-1R Tirzepatide displays unique pharmacology and is described as an imbalanced agonist