contraindications for glp 1 agonists include Are Serious Anesthesia Risks of Semaglutide and Other GLP-1 Under-Recognized? Case Reports of Retained Solid Gastric Contents in Patients Undergoing Anesthesia GLP-1 Therapy Part 1: Setting

Delayed gastric emptying may undergo tachyphylaxis, potentially reducing the impact of DDIs with repeated dosing

Orlistats main drawback is digestive: because the unabsorbed fat has to go somewhere, side effects like oily or loose bowel movements are common (especially after fatty meals)

A randomized, controlled trial of 3.0 mg of Liraglutide in weight management

Timeline: Women with PCOS often see fertility improvements within 2-4 months of starting GLP-1smuch faster than with metformin alone

For example, medications like Semaglutide and Tirzepatide, with their once-weekly dosing regimens, may have prolonged effects on gastric emptying of uncertain duration that persist beyond the medications active window, raising questions about the timing of preoperative fasting and the management of gastric residuals (Almandoz et al