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People with higher muscle mass and better cardiovascular fitness typically eliminate medications more efficiently
While not a true limitation, the data often portrayed a complex balance of effects and values such that no singular recommendations could be made for most KQs

Many insurance plans do not cover GLP-1 medications for type 1 diabetes, which can limit their use

Discontinuing glucagonlike peptide1 receptor agonists and body habitus: A systematic review and metaanalysis Berg 2025 Obesity Reviews Wiley Online Library [Internet]

This projection is speculative pending Phase 3 data but is supported by the trajectory of the published weight curves