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353 These findings confirm that in the synovium, GLP-1R is expressed on two different cell types, macrophages and fibroblast-like synoviocytes, which are specialized cells distributed within the synovial intima and subintima, and these cell types play important roles in hyaluronic acid synthesis, metabolite processing, and clearance of matrix degradation fragments

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If successful, this multi-agonist could fill the unmet need for NASH treatments

We also measured mitochondrial and peroxisomal FAO in the liver