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In fact, ADAs 2023 guidelines emphasize using a GLP-1 RA (or SGLT2 inhibitor) in patients with established ASCVD to reduce cardiovascular risk, independent of baseline A1c

Burke LE, Wang J, Sevick MA

Lowering inflammatory cytokines Studies in Nature and Diabetes show that GLP-1 reduces cytokines such as TNF-alpha, IL-6, and IL-1, which are major players in autoimmune diseases and arthritis

GLP-1 induces barrier protective expression in Brunners glands and regulates colonic inflammation

Zhang Y, Proenca R, Maffei, Barone M, Leopold L, Friedman JM
