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LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcomes Results) trial revealed that patients who received liraglutide had a lower risk of the primary composite outcome as listed above, cardiovascular death, death from any cause, and microvascular events than the placebo group [10]

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In rats, more severe effects were seen after maternal exposure to semaglutide in the form of visceral abnormalities and major skeletal malformations ( Table 1 )

Dipeptidyl peptidase-4 inhibitors and risk of heart failure in patients with type 2 diabetes mellitus: a population-based cohort study