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They often report cold intolerance, fatigue, poor hair quality and feeling "crap"
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The drug has a long half-life, which means it can be administered monthly or less frequently, giving the drug the potential to improve adherence and long-term weight control, according to Jay Bradner, executive vice president of research and development at Amgen
Orforglipron also appeared to be as safe and tolerable as other existing GLP-1 drugs
