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Liraglutide Versus Glimepiride Monotherapy for Type 2 Diabetes (LEAD-3 Mono): A Randomised, 52-Week, Phase III, Double-Blind, Parallel-Treatment Trial
The phase 2 study to evaluate the efficacy, safety and tolerability of maridebart cafraglutide is currently ongoing (ClinicalTrials.gov number, NCT05669599)

These effects were blunted in CNS-specific GIPR knockout mice, suggesting a key role of CNS GIPR in the control of energy metabolism (138) ( Figure 1 Section C)

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As estrogen declines, your metabolism, appetite signals, and where you store fat all change at once, which is why the strategies that used to work suddenly stop
