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There is also a separate safety question, distinct from efficacy: retatrutide raises resting heart rate by 5 to 10 beats per minute, which has not yet been characterised in patients who already have heart failure or irregular heartbeats

33 An international phase III RCT (RESOLVE-IT, NCT02704403) comparing elafibranor with placebo in NASH patients was terminated early due to insignificant efficacy but without significant adverse events at 72 weeks of treatment

Mike Haney: Yeah

It balances clinical evidence with financial reality and gives employers a documented, defensible policy

You start at 2.5 mg and gradually increase to 5 mg , then 7.5 mg , 10 mg , 12.5 mg , or 15 mg