semaglutide vs retatrutide Mounjaro vs Ozempic: 2026 Data Is Decisive Retatrutide vs Tirzepatide vs Semaglutide

NEW: Eli Lilly and Company's retatrutide, a first-in-class GIP, GLP-1, and glucagon triple hormone receptor agonist, met all primary and key secondary endpoints in the phase 3 TRIUMPH-4 trial in adults with obesity or overweight and knee osteoarthritis, and without diabetes, as an adjunct to healthy diet and physical activity

When levels drop, the first symptoms are typically fatigue and exercise intolerance, both of which are already common during caloric restriction and GLP-1 therapy

Ozempic (semaglutide) is a GLP-1 receptor agonist

The original development partner, Janssen Pharmaceuticals, has handed back the license for efinopegdutide to the original developer, Hanmi Pharmaceutical, but the license has been taken up by Merck to be developed as a once weekly treatment for NAFLD

For most adults, this translates to 80 to 130 grams per day