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doi: 10.1016/s0140-6736(02)07952-7, PMID: [DOI] [PubMed] [Google Scholar] 99

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Infections: vulvovaginal candidiasis, bacterial vaginosis, vulvovaginitis Comparative observational signal (protective association): In a phenome-wide association study comparing people with type 2 diabetes prescribed GLP-1 receptor agonists vs SGLT2 inhibitors and DPP4 inhibitors (NIH All of Us cohort, Jan 2018Oct 2023), semaglutide prescription was associated with reduced risk of diagnoses including candidiasis of vulva and vagina and inflammatory disease of cervix, vagina, and vulva compared with SGLT2 inhibitors

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Pharmacists should be aware of various causes of weight gain in midlife women, as well as pharmacotherapies, supplements, and OTC products that either could lead to weight gain or could assist with weight loss

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Research Applications & Usage Information Semaglutide (10 mg) is commonly used in laboratory research focused on: GLP-1 receptor activation and binding assays Incretin hormone signaling pathway investigations Studies of glucose metabolism and endocrine communication Cellular signaling and protein phosphorylation analysis Comparative research on long-acting peptide analogs Preclinical metabolic model development All uses are investigational and restricted to controlled in vitro or preclinical research settings

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P =0.02) than treatment with other glucose-lowering therapies [98]

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