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The LEADER Publication Committee on behalf of the LEADER Trial Investigators, Zinman B, Nauck MA, Bosch-Traberg H, Frimer-Larsen H, rsted DD, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Usdin TB, Mezey E, Button DC, Brownstein MJ, Bonner TI (1993) Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
These findings suggest that GLP-1 RAs confer modest BP-lowering effects as adjuncts to standard antihypertensive therapy in individuals with T2DM at elevated cardiovascular risk

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By starting at very low levels of receptor activation and increasing gradually, you allow the receptors to adapt without the dramatic desensitization that can occur with sudden, high-level activation