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By week 12, the appetite suppression reaches a stable plateau, meaning further dose increases produce diminishing appetite returns, though they may enhance other metabolic benefits

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Over time, this leads to consistent caloric reduction and meaningful weight loss without requiring extreme willpower or restrictive dieting

Setting realistic expectations is crucial: weight loss is gradual, with clinical trials showing approximately 15% weight reduction with semaglutide 2.4 mg at 68 weeks and up to 21% with tirzepatide at 72 weeks, though individual responses vary considerably