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Research has found that people taking semaglutide for weight management often experience an average weight loss of 10-15% of their initial body weight over a period of several months to a year

Optimising nutritional intake is paramount

Additionally, while clinical guidelines for indicated use of GLP-1 RAs are rapidly changing as evidence for GLP-1 RA use evolves, the ethics of off-label use are particularly important to consider given the impact these shortages can have on access for patients who otherwise have a strong clinical indication to be on them

Our findings are in keeping with previous reports by Nwokolo et al

This could be one reason why some people experience leg cramps when using semaglutide