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At Affinity Whole Health, we've seen similar results with our patients

Within days, the skin felt firmer, more supportedlike it was actually holding together better

10.1016/s0140-6736(20)32205-4 [DOI] [PMC free article] [PubMed] [Google Scholar] Scherer T., Sakamoto K., Buettner C

Ayoub M, Aibani R, Dodd T, et al

In that case, youd take your dose on Saturday as usual, then again on Wednesday (since more than 48 hours have passed)
