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Second, confounding by indication is likely, as GLP-1 RAs are prescribed primarily to individuals with type 2 diabetes or obesity, who differ from lithium-treated patients in metabolic risk, renal surveillance intensity, and access to nephrology care

Semaglutide alone may not cause depression, but it can act as a catalyst in people who already have fragile mood regulation

This includes stimulants such as those used to treat attention-deficit/hyperactivity disorder (ADHD), decongestants used for colds, and even high doses of caffeine or energy drinks