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Then came Wegovy, a high-dose version officially marketed as an obesity treatment

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It targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)

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A PPAR-dependent mechanism was also found to regulate the expression of the Gipr in beta cells by glucose and fat [22]

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Both medications can lead to substantial weight loss when combined with lifestyle changes

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Beyond their direct impact on pancreatic cells, GLP-1 receptor agonists interact with other components of the endocrine system

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