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Bain SC, Mosenzon O, Arechavaleta R, et al

Macrophages: development and tissue specialization

Semaglutide, also via GLP-1R/cAMP signaling, promoted mitochondrial biogenesis by increasing levels of PGC-1 and SIRT1 and antioxidant activity through the expression of the NRF2-regulated antioxidant genes [183]

This approach complements the effects of GLP-1 agonists and improves long-term metabolic health
