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In subjects with T2DM, weekly administration of tirzepatide at doses of 5 mg, 10 mg, or 15 mg was associated with greater weight loss compared to placebo ( 6.3 kg, 8.4 kg, and 9.4 kg, respectively), and 1.7 kg, 4.8 kg, and 7.2 kg greater weight loss compared to selective GLP-1 receptor agonists, demonstrating a dose-dependent effect sustained for up to 2 years [48]

There was an absence of standardization in what constituted the eye evaluations, how they were performed and their intervals

Many recent studies also focus on the metabolic aspects of depression, suggesting the involvement of peripheral and central impairments in energy homeostasis, mitochondrial dysfunction, as well as disturbances in the gut-brain axis and gut microbiota dysbiosis as noteworthy factors in the pathogenesis of depression [6,7,8,9]

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The results showed that more than 95% of the cells stained positive for calponin