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Physicians have to monitor indicators such as blood sugar and metabolic status

In the Phase 2 clinical trial, obese patients treated with a 12-milligram dose for 48 weeks experienced an average weight reduction of 24.2% (approximately 58 pounds/26.2 kilograms), significantly better than the 2.1% reduction in the placebo group

Curr Opin Endocrinol Diabetes Obes 5(4):252255 Sun EW, Martin AM, Wattchow DA et al (2019) Metformin triggers PYY secretion in human gut mucosa

If someone on both medications experiences low energy or increased hunger, they might struggle more to lose weight

muciniphila , a bacterium most people naturally carry in their gut, though levels tend to be lower in people with obesity, diabetes or inflammatory bowel disease (IBD)