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Dehydration represents a clinically significant risk for patients taking GLP-1 medications, particularly during the initial weeks of therapy or following dose increases when gastrointestinal side effects are most pronounced

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[25] also discovered dual agonists targeting both GLP-1 and GIP receptors (GIPR)

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38 , 39 , 40 There are no clinical data on the simultaneous effect of GIP, GLP1, and glucagon receptor agonism on appetite and eating constructs