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The approvalGerons first after 34 years in businesswas supported by data from the Phase III IMerge trial, in which patients on Rytelo had significantly higher rates of red blood cell transfusion independence over placebo for at least 24 weeks28% in the treatment arm versus 3% on placebo

Emerging concerns include potential effects on muscle mass loss during rapid weight loss and reports of suicidal ideation

Also, cravings can return

[4] [5] The tablet should be swallowed whole (not split, crushed or chewed)

Restrictive diets of any kind are not appropriate for pregnant or breastfeeding women, children and young people, or individuals with or at risk of an eating disorder