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In addition, the duration of these two trials are shorter which may also lead to heterogeneity.It is because GADE mainly occurs in the first weeks of administration.The short duration may increase the difference between TZP and placebo groups but not GLP1-RAs

Abdominal pain, persistent nausea, or vomiting may indicate pancreatitisa rare but serious adverse effect requiring immediate medical attention

Headaches: Common in the first week or two, usually resolving as the body adjusts

Individual response varies genetics, baseline metabolic health, and how well GI side effects are tolerated all influence final outcomes

In total around 220,000 people are expected to benefit in this initial three year roll out period